Article
SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease.
The Journal of clinical investigation - 17 Sept 2024
Ren Wenyan, Hong Weiqi, Yang Jingyun, Zou Jun, Chen Li, Zhou Yanan, Lei Hong, Alu Aqu, Que Haiying, Gong Yanqiu, Bi Zhenfei, He Cai, Fu Minyang, Peng Dandan, Yang Yun, Yu Wenhai, Tang Cong, Huang Qing, Yang Mengli, Li Bai, Li Jingmei, Wang Junbin, Ma Xuelei, Hu Hongbo, Cheng Wei, Dong Haohao, Lei Jian, Chen Lu, Zhou Xikun, Li Jiong, Wang Wei, Lu Guangwen, Shen Guobo, Yang Li, Yang Jinliang, Wang Zhenling, Jia Guowen, Su Zhaoming, Shao Bin, Miao Hanpei, Yiu-Nam Lau Johnson, Wei Yuquan, Zhang Kang, Dai Lunzhi, Lu Shuaiyao, Wei Xiawei
Abstract excerpt
Soluble host factors in the upper respiratory tract can serve as the first line of defense against SARS-CoV-2 infection. In this study, we described the identification and function of a human airway trypsin-like protease (HAT), capable of reducing the infectivity of ancestral SARS-CoV-2. Further, in mouse models, HAT analogue expression was upregulated by SARS-CoV-2 infection. The antiviral activity of HAT...
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