Article

Activation of SARS-CoV-2 by trypsin-like proteases in the clinical specimens of patients with COVID-19

2022-09-28

Abstract excerpt

SARS-CoV-2 enters host cells through the angiotensin converting enzyme 2 (ACE2) receptor and/or transmembrane protease, serine 2 (TMPRSS2). Serine proteases, such as TMPRSS2 and trypsin, promote viral entry. In this study, we investigated whether proteases increased SARS-CoV-2 infectivity using pseudotyped viruses and clinical specimens from patients with COVID-19. First, we investigated how trypsin increased infe...

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Literature Corpus work: 1dc0ce4f-ba92-5468-815e-0e4bf644a6bd
DOI: 10.1101/2022.09.27.509803

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