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TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells

17 Sept 2015

Abstract excerpt

The cellular protease TMPRSS2 cleaves and activates the influenza virus hemagglutinin (HA) and TMPRSS2 expression is essential for viral spread and pathogenesis in mice. Moreover, severe acute respiratory syndrome coronavirus (SARS-CoV) and other respiratory viruses are activated by TMPRSS2. However, previous studies on viral activation by TMPRSS2 focused on a 492 amino acids comprising form of the protein...

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PMID: 26379044
DOI: 10.1371/journal.pone.0138380

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