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Article

A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.

Nature communications - 10 Feb 2021

Zhang Yiqun, Chen Fengju, Donehower Lawrence A, Scheurer Michael E, Creighton Chad J

Abstract excerpt

The global impact of somatic structural variants (SSVs) on gene expression in pediatric brain tumors has not been thoroughly characterised. Here, using whole-genome and RNA sequencing from 854 tumors of more than 30 different types from the Children's Brain Tumor Tissue Consortium, we report the altered expression of hundreds of genes in association with the presence of nearby SSV breakpoints. SSV-mediated...

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Brain Neoplasms
Cohort Studies
Exome Sequencing
Gene Expression Regulation, Neoplastic
Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, RNA

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PMID: 33568653
DOI: 10.1038/s41467-021-21081-y
PMCID: PMC7876141

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