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Article

Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications.

EBioMedicine - 1 Jul 2016

Cresswell George D, Apps John R, Chagtai Tasnim, Mifsud Borbala, Bentley Christopher C, Maschietto Mariana, Popov Sergey D, Weeks Mark E, Olsen Øystein E, Sebire Neil J, Pritchard-Jones Kathy, Luscombe Nicholas M, Williams Richard D, Mifsud William

Abstract excerpt

The evolution of pediatric solid tumors is poorly understood. There is conflicting evidence of intra-tumor genetic homogeneity vs. heterogeneity (ITGH) in a small number of studies in pediatric solid tumors. A number of copy number aberrations (CNA) are proposed as prognostic biomarkers to stratify patients, for example 1q+ in Wilms tumor (WT); current clinical trials use only one sample per tumor to profile this...

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Identifiers

PMID: 27333041
DOI: 10.1016/j.ebiom.2016.05.029
PMCID: PMC4972528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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