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Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra.

Cancer research - 15 Jan 2017

Chmielecki Juliann, Bailey Mark, He Jie, Elvin Julia, Vergilio Jo-Anne, Ramkissoon Shakti, Suh James, Frampton Garrett M, Sun James X, Morley Samantha, Spritz Daniel, Ali Siraj, Gay Laurie, Erlich Rachel L, Ross Jeffrey S, Buxhaku Joana, Davies Hilary, Faso Vinny, Germain Alexis, Glanville Blair, Miller Vincent A, Stephens Philip J, Janeway Katherine A, Maris John M, Meshinchi Soheil, Pugh Trevor J, Shern Jack F, Lipson Doron

Abstract excerpt

Pediatric cancers are generally characterized by low mutational burden and few recurrently mutated genes. Recent studies suggest that genomic alterations may help guide treatment decisions and clinical trial selection. Here, we describe genomic profiles from 1,215 pediatric tumors representing sarcomas, extracranial embryonal tumors, brain tumors, hematologic malignancies, carcinomas, and gonadal tumors....

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Adolescent
Child
Child, Preschool
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Source

Open in PubMed Open full text

Identifiers

PMID: 28069802
DOI: 10.1158/0008-5472.CAN-16-1106
PMCID: PMC8191391

Genes

ALK
BRAF
PAX3
BCAS1
BEND5
GLI2
NTRK1
PRSS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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