Article

Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin Activity

2023-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Cholesterol dependent cytolysins (CDCs) are a large family of pore forming toxins, produced by numerous gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface associated human CD59 (hCD59) for binding, conferring specificity for human cells. We purified a recombinant version of a putative CDC encoded in the genome of Streptococcus or...

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Literature Corpus work: ce55a3b9-d41a-5a8a-a6ef-3184397f3c3b
DOI: 10.1101/2023.06.21.545930

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