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Article

Cytotoxic property of Streptococcus mitis strain producing two different types of cholesterol-dependent cytolysins.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2020

Tabata Atsushi, Ohkuni Hisashi, Hino Haruka, Saigo Takuya, Kodama Chihiro, Tang Qing, Tomoyasu Toshifumi, Fukunaga Yoshitaka, Itoh Yasuhiko, Nagamune Hideaki

Abstract excerpt

Streptococcus mitis strain Nm-65 secretes an atypical 5-domain-type cholesterol-dependent cytolysin (CDC) called S. mitis-derived human platelet aggregation factor (Sm-hPAF) originally described as a platelet aggregation factor. Sm-hPAF belongs to Group III CDC that recognize both membrane cholesterol and human CD59 as the receptors, and shows preferential activity towards human cells. Draft genome analyses have...

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Identifiers

PMID: 32731044
DOI: 10.1016/j.meegid.2020.104483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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