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Article

Crystal structure of cytotoxin protein suilysin from Streptococcus suis

1 Jan 2010

Abstract excerpt

Cholesterol-dependent cytolysins (CDC) are pore forming toxins. A prototype of the CDC family members is perfringolysin O (PFO), which directly binds to the cell membrane enriched in cholesterol, causing cell lysis. However, an exception of this general observation is intermedilysin (ILY) of Streptococcus intermedius, which requires human CD59 as a receptor in addition to cholesterol for its hemolytic activity. A...

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PMID: 21204001
DOI: 10.1007/s13238-010-0012-3

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