Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Cytolytic Activity of Vaginolysin Strictly Depends on Cholesterol and Is Potentiated by Human CD59

13 Jan 2015

Abstract excerpt

Gardnerella vaginalis produces cytolysin vaginolysin (VLY), which has been suggested to be a contributor to bacterial vaginosis pathogenesis. VLY along with intermedilysin (ILY) from Streptococcus intermedius have been attributed to a group of cholesterol-dependent cytolysins (CDCs) whose pore-forming activity depends on human CD59 (hCD59). Here, we show that different types of cells lacking hCD59 are susceptible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Reproductive System and Pregnancy
Share to Reproductive tract infections research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25590277
DOI: 10.3390/toxins7010110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Cytolytic Activity of Vaginolysin Strictly Depends on Cholesterol and Is Potentiated by Human CD59PMID 25590277Read ↗

Functional and Phylogenetic Characterization of Vaginolysin, the Human-Specific Cytolysin from<i>Gardnerella vaginalis</i>Semantic proximity Read ↗

Reconstitution of cholesterol-dependent vaginolysin into tethered phospholipid bilayers: implications for bioanalysis.Semantic proximity Read ↗

Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin ActivitySemantic proximity Read ↗

Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners.Semantic proximity Read ↗

Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysinSemantic proximity Read ↗

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.Semantic proximity Read ↗

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.Semantic proximity Read ↗

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formationSemantic proximity Read ↗

Generation of dimeric single-chain antibodies neutralizing the cytolytic activity of vaginolysinSemantic proximity Read ↗

Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by <i>Streptococcus intermedius</i>Semantic proximity Read ↗

Structural basis for tuning activity and membrane specificity of bacterial cytolysins.Semantic proximity Read ↗

Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.