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Article

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.

Structure (London, England : 1993) - 6 Sept 2016

Lawrence Sara L, Gorman Michael A, Feil Susanne C, Mulhern Terrence D, Kuiper Michael J, Ratner Adam J, Tweten Rodney K, Morton Craig J, Parker Michael W

Abstract excerpt

Cholesterol-dependent cytolysins (CDCs) are a family of pore-forming toxins that punch holes in the outer membrane of eukaryotic cells. Cholesterol serves as the receptor, but a subclass of CDCs first binds to human CD59. Here we describe the crystal structures of vaginolysin and intermedilysin complexed to CD59. These studies, together with small-angle X-ray scattering, reveal that CD59 binds to each at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27499440
DOI: 10.1016/j.str.2016.06.017
PMCID: PMC5320943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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