Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pneumolysin: Pathogenesis and Therapeutic Target

2 Jul 2020

Abstract excerpt

Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness and is a major global health issue for children, the elderly, and the immunocompromised population. Pneumolysin is a cholesterol-dependent cytolysin (CDC) and key pneumococcal virulence factor involved in all phases of pneumococcal disease, including transmission, colonization, and infection. In this review we cover the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pneumocystis jirovecii pneumonia detection and treatment
Share to Pneumonia and Respiratory Infections
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32714314
DOI: 10.3389/fmicb.2020.01543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pneumolysin: Pathogenesis and Therapeutic TargetPMID 32714314Read ↗

Pneumolysin: A Double-Edged Sword During the Host-Pathogen InteractionSemantic proximity Read ↗

The Global Burden of Community-Acquired Pneumonia, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, With a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and TherapySemantic proximity Read ↗

The cholesterol-dependent cytolysin pneumolysin from Streptococcus pneumoniae binds to lipid raft microdomains in human corneal epithelial cells.Semantic proximity Read ↗

Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase ASemantic proximity Read ↗

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.Semantic proximity Read ↗

Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression.Semantic proximity Read ↗

Detoxified pneumolysin derivative Plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines.Semantic proximity Read ↗

Structure-based functional studies for the cellular recognition and cytolytic mechanism of pneumolysin from Streptococcus pneumoniae.Semantic proximity Read ↗

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle ArrestSemantic proximity Read ↗

Cytotoxic property of Streptococcus mitis strain producing two different types of cholesterol-dependent cytolysins.Semantic proximity Read ↗

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyleSemantic proximity Read ↗

Interaction of Macrophages and Cholesterol-Dependent Cytolysins: The Impact on Immune Response and Cellular SurvivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.