Article

APOE4 genotype is associated with CSF activated PKR levels in patients with Alzheimer's disease

2026-06-21

Abstract excerpt

<title>Abstract</title> <p>Objective Protein kinase R (PKR) is a stress-activated kinase implicated in translational control, neuroinflammation, and neurodegeneration. Although increased PKR activation was reported in Alzheimer’s disease (AD), prior studies relied on semi-quantitative methods. This study aimed to quantitatively assess cerebrospinal fluid (CSF) levels of total PKR and phosphorylated PKR (pPKR) in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce500159-438d-564b-b255-bb587017a3a3
DOI: 10.21203/rs.3.rs-9987034/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOE4 genotype is associated with CSF activated PKR levels in patients with Alzheimer's diseaseDOI 10.21203/rs.3.rs-9987034/v1Read

Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson DiseaseSemantic proximity Read

Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s diseaseSemantic proximity Read

MicroRNAs and MAPKs: Evidence of These Molecular Interactions in Alzheimer’s DiseaseSemantic proximity Read

The Potential Role of Protein Kinase R as a Regulator of Age-Related NeurodegenerationSemantic proximity Read

Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s diseaseSemantic proximity Read

Neurodegeneration Risk Factor, <i>EIF2AK3</i> ( <i>PERK</i> ), Influences Tau Protein AggregationSemantic proximity Read

Lymphocytes from young healthy persons carrying the ApoE4 allele overexpress stress-related proteins involved in the pathophysiology of Alzheimer's disease.Semantic proximity Read

Serum Levels of Clusterin, PKR, and RAGE Correlate with Amyloid Burden in Alzheimer’s DiseaseSemantic proximity Read

Analytical and Clinical Validation of a High Accuracy Fully Automated Digital Immunoassay for Plasma Phospho-Tau 217 for Clinical Use in Detecting Amyloid PathologySemantic proximity Read

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.Semantic proximity Read

Prospective Role of PAK6 and 14-3-3γ as Biomarkers for Parkinson's Disease.Semantic proximity Read

The human-specific<i>CASP4</i>gene product contributes to Alzheimer-related synaptic and behavioural deficitsSemantic proximity Read