Back to search

Article

Analytical and Clinical Validation of a High Accuracy Fully Automated Digital Immunoassay for Plasma Phospho-Tau 217 for Clinical Use in Detecting Amyloid Pathology

2024-11-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Phospho-tau 217 (p-Tau 217) in plasma has emerged as a promising biomarker for detecting amyloid pathology in plasma as an aid in diagnosis of Alzheimer’s disease. Because of its low abundance in plasma, reliable quantitation in blood is challenging. Digital single molecule array (Simoa) technology provides higher analytical sensitivity than possible with conventional analog i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d468343d-8547-532e-a6c5-19216c4aa068
DOI
10.1101/2024.10.31.24316186
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Analytical and Clinical Validation of a High Accuracy Fully Automated Digital Immunoassay for Plasma Phospho-Tau 217 for Clinical Use in Detecting Amyloid PathologyDOI 10.1101/2024.10.31.24316186
Development and clinical validation of blood-based multibiomarker models for the evaluation of brain amyloid pathologySemantic proximity
A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker TestsSemantic proximity
Multi-Platform Comparison of Plasma Phosphorylated Tau Assays: Analytical and Workflow Factors Drive Clinical Implementation DecisionsSemantic proximity
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer’s diseaseSemantic proximity
Robustness of plasma p-Tau217 diagnostic thresholds for Alzheimer’s disease across various clinical populations and laboratory environmentsSemantic proximity
The Alzheimers Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin studySemantic proximity
CNS-selective plasma p-tau217 accurately captures Alzheimer’s disease pathology and progressionSemantic proximity
Association of Plasma Phosphorylated Tau 217 With Clinical Deterioration Across Alzheimer Disease StagesSemantic proximity
Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s diseaseSemantic proximity
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders.Semantic proximity
Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementiaSemantic proximity
High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed dementia cohortSemantic proximity
Select a neighboring publication to make it the new centre.