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Article

The human-specific<i>CASP4</i>gene product contributes to Alzheimer-related synaptic and behavioural deficits

11 Aug 2016

Abstract excerpt

Recent studies have indicated that innate immune signalling molecules are involved in late-onset Alzheimer's disease (LOAD) risk. Amyloid beta (Aβ) accumulates in AD brain, and has been proposed to act as a trigger of innate immune responses. Caspase-4 is an important part of the innate immune response. We recently characterized transgenic mice carrying human CASP4, and observed that the mice manifested profound...

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PMID: 27516385
DOI: 10.1093/hmg/ddw265

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