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Article

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.

Molecular cell - 7 Sept 2017

Wang Zhi-Hao, Liu Pai, Liu Xia, Manfredsson Fredric P, Sandoval Ivette M, Yu Shan Ping, Wang Jian-Zhi, Ye Keqiang

Abstract excerpt

Delta-secretase, a lysosomal asparagine endopeptidase (AEP), simultaneously cleaves both APP and tau, controlling the onset of pathogenesis of Alzheimer's disease (AD). However, how this protease is post-translationally regulated remains unclear. Here we report that serine-arginine protein kinase 2 (SRPK2) phosphorylates delta-secretase and enhances its enzymatic activity. SRPK2 phosphorylates serine 226 on...

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Share to Amyloid Precursor Protein Secretases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28826672
DOI: 10.1016/j.molcel.2017.07.018
PMCID: PMC5753427

Genes

SRPK2
APP

Variants

Provenance

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