Article

Neurodegeneration Risk Factor, <i>EIF2AK3</i> ( <i>PERK</i> ), Influences Tau Protein Aggregation

2022-12-15

Abstract excerpt

Tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. Population studies implicate EIF2AK3 ( eukaryotic translation initiation factor 2 alpha kinase 3 ), better known as PERK ( protein kinase R-like endoplasmic reticulum kinase ), as a genetic risk factor in several tauopathies. PERK is a key regulator of intracellular proteostatic mechanisms –...

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Literature Corpus work: ae028ad9-86d4-54f6-995d-c6476811252f
DOI: 10.1101/2022.12.14.520487

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