Article

Elucidating conformational alteration of human islet amyloid polypeptide by nonsynonymous substitution

2024-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Islet amyloid polypeptide (IAPP) is a peptide hormone that serves multiple essential functions, including metabolism and regulating gastric emptying and satiation through amylin receptors. However, mutations in the IAPP , notably in the amyloidogenic segment (20-29 amino acid residues), cause its aggregation and amyloid formation, which leads to β-cell toxicity and death in type 2 diabetes mell...

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Literature Corpus work: ce468cd0-81f0-5365-8ed3-27941db71255
DOI: 10.1101/2024.11.16.623924

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