Article

Structural effects driven by rare point mutations in amylin hormone, the type II diabetes-associated peptide

2021-02-18

Abstract excerpt

<h4>Background</h4> Amylin is a 37-amino-acid peptide hormone co-secreted with insulin, which participates in glucose homeostasis. This hormone is able to aggregate in a β-sheet conformation and deposit in islet amyloids, a hallmark in type II diabetes. Since amylin is a gene-encoded hormone, this peptide has variants caused by point mutations that can impact its functions. <h4>Methods</h4> Here, we analyzed the...

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Literature Corpus work: ffb262b5-21c9-5cc6-97d2-b37c6e1d5f12
DOI: 10.1101/2021.02.17.431675

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