Article

Comprehensive Computational Analysis Revealed Seven Novel Mutations in Human Insulin gene

2022-05-23

Abstract excerpt

<h4>Background: </h4> Insulin gene mapped on chromosome 11p15.5 consists of 3 exons, which translated to 51 residues of small globular protein secreted from the secretory granules in β-cells of the pancreatic gland. In this study, we used various computational approaches to identify nsSNPs, which probably be deleterious to the structure and/or function of insulin protein that might be associated with different dis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74648ceb-ab72-5865-9f2f-d42b3836207d
DOI: 10.21203/rs.3.rs-1604875/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Computational Analysis Revealed Seven Novel Mutations in Human Insulin geneDOI 10.21203/rs.3.rs-1604875/v1Read

Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor.Semantic proximity Read

In Silico Analysis of Effect of Non-synonymous SNPs associated with Permanent Neonatal Diabetes Mellitus on Stability and Structure of Human InsulinSemantic proximity Read

Elucidating conformational alteration of human islet amyloid polypeptide by nonsynonymous substitutionSemantic proximity Read

In-Silico Investigation of Effects of Single-Nucleotide Polymorphisms in PCOS-Associated CYP11A1 Gene on Mutated Proteins.Semantic proximity Read

Unraveling the potential effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on the Protein structure and function of the human SLC30A8 gene on type 2 diabetes and colorectal cancer: An In silico approachSemantic proximity Read

A Review of the Biosynthesis and Structural Implications of Insulin Gene Mutations Linked to Human Disease.Semantic proximity Read

In celebration of a century with insulin - Update of insulin gene mutations in diabetes.Semantic proximity Read

Structural Consequences of IRS-2 nsSNPs and Implication for Insulin Receptor Substrate-2 Protein Stability.Semantic proximity Read

[Insulin gene mutations].Semantic proximity Read

In silico analysis of non-synonymous missense SNPs (nsSNPs) in CPE, GNAS genes and experimental validation in type II diabetes mellitus through Next Generation Sequencing.Semantic proximity Read

Genetic Variants Affecting Insulin Signaling Pathways and Risk of Diabetes: A Comprehensive Systematic ReviewSemantic proximity Read

Structural Basis and Genotype-Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance.Semantic proximity Read