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Article

Structural and functional characterization of pathogenic non- synonymous genetic mutations of human insulin-degrading enzyme by in silico methods.

CNS & neurological disorders drug targets - 1 Apr 2014

Shaik Noor A, Kaleemuddin Mohammed, Banaganapalli Babajan, Khan Fazal, Shaik Nazia S, Ajabnoor Ghada, Al-Harthi Sameer E, Bondagji Nabeel, Al-Aama Jumana Y, Elango Ramu

Abstract excerpt

Insulin-degrading enzyme (IDE) is a key protease involved in degrading insulin and amyloid peptides in human body. Several non-synonymous genetic mutations of IDE gene have been recently associated with susceptibility to both diabetes and Alzheimer's diseases. However, the consequence of these mutations on the structure of IDE protein and its substrate binding characteristics is not well elucidated. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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PMID: 24059301
DOI: 10.2174/18715273113126660161

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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