Article

Massively parallel quantification of mutational impact on IAPP amyloid formation

2025-05-23

Abstract excerpt

Amyloid fibrils formed by the islet amyloid polypeptide (IAPP) cause pancreatic beta-cell damage, resulting in reduced insulin secretion and Type 2 diabetes (T2D). Variations in the primary amino acid sequence of IAPP can influence its aggregation rate and animals expressing IAPP variants that do not form amyloids, do not develop T2D. Conversely, specific single amino-acid changes in IAPP are enough to accelerate...

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Literature Corpus work: 752ed2fc-1e43-5f12-abfd-690673ccc39c
DOI: 10.1101/2025.05.19.654797

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