Experimental and computational analysis of the basis for accelerated amyloid formation by a disease linked mutant of human islet amyloid polypeptide.

Abstract excerpt

The process of islet amyloid formation by the polypeptide hormone human IAPP contributes to the loss of β-cell function in type-2 diabetes. The S20G mutation in human IAPP has been linked to an increased risk of diabetes in individuals of Japanese and Chinese ancestry and leads to more rapid amyloid formation in vitro. The molecular basis of the S20G enhancement of amyloid formation was explored via experiments...

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