Article

Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects

2023-06-27

Abstract excerpt

Bulk tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting disease-associated variants, while context-specific QTLs show particular relevance for disease. Here, we present the results of mapping interaction QTLs (iQTLs) for cell type, age, and other phenotypic variables in multi-omic, longitudinal data from blood of individuals of diverse ancestries. By modeling the interact...

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Literature Corpus work: ce4253bb-2f72-5fdd-87d9-1c812f4be772
DOI: 10.1101/2023.06.26.546528

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