Article
Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects.
American journal of human genetics - 4 Jan 2024
Kasela Silva, Aguet François, Kim-Hellmuth Sarah, Brown Brielin C, Nachun Daniel C, Tracy Russell P, Durda Peter, Liu Yongmei, Taylor Kent D, Johnson W Craig, Van Den Berg David, Gabriel Stacey, Gupta Namrata, Smith Joshua D, Blackwell Thomas W, Rotter Jerome I, Ardlie Kristin G, Manichaikul Ani, Rich Stephen S, Barr R Graham, Lappalainen Tuuli
Abstract excerpt
Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting disease-associated variants, and context-specific QTLs show particular relevance for disease. Here, we present the results of mapping interaction QTLs (iQTLs) for cell type, age, and other phenotypic variables in multi-omic, longitudinal data from the blood of individuals of diverse ancestries. By modeling the...
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