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Article

SIV infection duration largely determines broadening of neutralizing antibody response in macaques.

The Journal of clinical investigation - 1 Oct 2020

Wu Fan, Ourmanov Ilnour, Kirmaier Andrea, Leviyang Sivan, LaBranche Celia, Huang Jinghe, Whitted Sonya, Matsuda Kenta, Montefiori David, Hirsch Vanessa M

Abstract excerpt

The development of broadly neutralizing antibodies (BNAbs) in HIV infection is a result of long-term coevolutionary interaction between viruses and antibodies. Understanding how this interaction promotes the increase of neutralization breadth during infection will improve the way in which AIDS vaccine strategies are designed. In this paper, we used SIV-infected rhesus macaques as a model to study the development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32663192
DOI: 10.1172/JCI139123
PMCID: PMC7524488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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