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Integrated left ventricular multi-omics landscape of human cardiometabolic HFpEF.

Cardiovascular research - 5 Jun 2026

Capone Federico, Rommel Karl-Philipp, Forbes Martin, Fahjen Pauline, Strocchi Stefano, Rosch Sebastian, Wang Rongling, Bode David, Nambiar Natasha, Eroglu Tolga, Padilla Leandro Santiago, Morieri Mario Luca, Liu Luo, Farrelly Catherine, Vacca Antonio, Mastrobuoni Guido, Jung Simone, Diezel Saskia A, Liévano Contreras Sarah V, Hübner Norbert, Mertins Philipp, Kempa Stefan, Lurz Philipp, Schiattarella Gabriele G

Abstract excerpt

AIMS: Heart failure with preserved ejection fraction (HFpEF), now the leading form of heart failure, is burdened by high morbidity and mortality, owing to gaps in our understanding of its molecular and pathophysiological mechanisms. The obese/cardiometabolic HFpEF phenotype is particularly prevalent and morbid, and obesity is increasingly recognized as a driver of the syndrome, though the underlying mechanisms...

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Heart Failure
Lipidomics
Metabolome
Metabolomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ventricular Function, Left

Ventricular Remodeling

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PMID: 42025317
DOI: 10.1093/cvr/cvag084

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EMB

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