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Article

Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis.

Journal of cardiovascular translational research - 30 Jun 2026

Xue Yuzhou, Liu Lin, Xu Ming, Jin Ling

Abstract excerpt

Heart failure (HF) is a heterogeneous syndrome with diverse etiologies, yet the metabolic determinants specific to its subtype remain unclear. We performed an integrative multi-omics analysis combining metabolomics, genetics, and single-cell transcriptomics to characterize metabolic signatures of distinct HF subtypes. By applying Mendelian randomization of 1,091 circulating metabolites, we identified distinct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42380371
DOI: 10.1007/s12265-026-10803-6

Genes

OGDHL
CBS
NEU3
PLD2
SHMT1
SULT1A1
UPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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