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The <i>C. albicans</i> virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

2021-11-12

Abstract excerpt

The pathogenic fungus Candida albicans causes severe invasive candidiasis. C. albicans infection requires the action of the virulence factor Candidalysin (CL), which damages the plasma membrane of the target human cells. However, the molecular mechanism that CL uses to permeabilize membranes is poorly understood. We employed complementary biophysical, modeling, microscopy, and cell biology methods to reveal that...

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Literature Corpus work
ce0dccad-a50d-5de0-9ed8-05dc763e6cf2
DOI
10.1101/2021.11.11.468266
Open publication

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