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Mechanisms protecting host cells against bacterial pore-forming toxins

27 Dec 2018

Abstract excerpt

Pore-forming toxins (PFTs) are key virulence determinants produced and secreted by a variety of human bacterial pathogens. They disrupt the plasma membrane (PM) by generating stable protein pores, which allow uncontrolled exchanges between the extracellular and intracellular milieus, dramatically disturbing cellular homeostasis. In recent years, many advances were made regarding the characterization of conserved...

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PMID: 30591958
DOI: 10.1007/s00018-018-2992-8

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