Chemical screening identifies filastatin, a small molecule inhibitor of <i>Candida albicans</i> adhesion, morphogenesis, and pathogenesis

Abstract excerpt

Infection by pathogenic fungi, such as Candida albicans, begins with adhesion to host cells or implanted medical devices followed by biofilm formation. By high-throughput phenotypic screening of small molecules, we identified compounds that inhibit adhesion of C. albicans to polystyrene. Our lead candidate compound also inhibits binding of C. albicans to cultured human epithelial cells, the yeast-to-hyphal...

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