Article

Sphingolipids protect ergosterol in the <i>Leishmania major</i> membrane from sterol-specific toxins

2022-06-15

Abstract excerpt

Susceptibility of Leishmania to the first line treatment amphotericin B remains poorly understood. Amphotericin B targets ergosterol, so one approach to improving drug efficacy and reducing side effects could be improving access to ergosterol. While the surface exposure of ergosterol in Leishmania is unknown, sterols in mammalian cells can be sheltered from sterol-binding agents by membrane components, including...

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Literature Corpus work: dabf2821-eaa9-5b10-81ef-44995accb0d6
DOI: 10.1101/2022.06.15.496300

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