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A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by <i>Candida albicans</i>

2024-05-23

Abstract excerpt

Candidalysin is a cytolytic peptide produced by the opportunistic fungal pathogen Candida albicans. This peptide is a key virulence factor in mouse models of mucosal and hematogenously disseminated candidiasis. Despite intense interest in the role of candidalysin in C. albicans pathogenicity, its host cell targets have remained elusive. To fill this knowledge gap, we performed a genome-wide loss-of-function CRIS...

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Literature Corpus work
f3f4b449-a6b1-5033-9853-d48e73b1b147
DOI
10.1101/2024.05.23.595417
Open publication

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A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by <i>Candida albicans</i>DOI 10.1101/2024.05.23.595417
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