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Engineering Dual-Target Chimeric Lysins for Synergistic Eradication of <i>Porphyromonas gingivalis</i>

2026-04-29

Abstract excerpt

Periodontitis is a chronic inflammatory disease driven by complex subgingival multispecies biofilms, in which Porphyromonas gingivalis plays a central role in coordinating microbial interactions. Together with host-associated factors, these microbial communities create dual constraints that limit antimicrobial efficacy. In this study, we engineered a library of recombinant lysins by fusing membrane-destabilizing...

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Literature Corpus work
62891c0f-4df7-5b0c-83f7-1ef1496de7d1
DOI
10.64898/2026.04.27.720852
Open publication

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