Article

Trymethylamine-N-oxide, a gut-derived metabolite, induces myofibroblastic activation of valvular interstitial cells through endoplasmic reticulum stress

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Calcific aortic valve disease currently lacks effective treatments beyond surgical valve replacement, due to an incomplete understanding of its pathogenesis. Emerging evidence suggests that the gut microbiome influences cardiovascular health through the production of metabolites derived from dietary components. Among them, trimethylamine-N-oxide (TMAO) has been identified as a potential causal f...

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Literature Corpus work: cde5ca57-1dd5-5f1e-982f-9ba541ca3c8f
DOI: 10.1101/2025.02.06.636980

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