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Trimethylamine- N -oxide formation, the bacterial taxa involved and intervention strategies to reduce its concentration in the human body

1 Jul 2025

Abstract excerpt

INTRODUCTION: -oxide (TMAO) formation, a gut microbiota (GM)-derived compound that promotes cardiovascular and chronic kidney disease. The formation of TMAO is a metaorganismal process, where trimethylamine (TMA), produced from the dietary precursors betaine, L-carnitine and choline by various members of GM, is absorbed and subsequently oxidized by hepatic flavin-containing monooxygenases before entering the...

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PMID: 40598778
DOI: 10.1080/07853890.2025.2525403

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