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Tryptophan-Kynurenine shunt and depletion of indole-producing Firmicutes: A new Gut-Heart axis in Calcific Aortic Stenosis (GUT-CAS)

2026-05-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Calcific aortic stenosis (CAS) is a progressive valvular disease characterized by lipid accumulation, inflammation, and osteogenic remodeling. Emerging evidence implicates gut microbiota-derived metabolites in cardiovascular pathology, yet their contribution to valvular disease remains poorly defined. The aim of this study was to investigate gut microbiota and metabolite s...

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Literature Corpus work: cc01ad72-ed49-5b2a-8504-74abc4d19759
DOI: 10.64898/2026.05.22.26353844

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