Article

Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Regions of the MiGut 3-Compartment <em>In Vitro</em> Colon Microbiome Model

2025-07-01

Abstract excerpt

<h4>Background: </h4> /Objectives: Gut microbial metabolism of choline and related quaternary amines to trimethylamine (TMA) is the first step in production of trimethylamine N-oxide (TMAO), a circulating metabolite that contributes to the development of atherosclerosis and other forms of cardiovascular disease (CVD). No data exist on regional differences in TMA production within the colon due to difficulties stud...

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Literature Corpus work: 840d3406-bfef-5ef9-980d-1012ff79f1e0
DOI: 10.20944/preprints202506.2492.v1

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