Article

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

2023-05-22

Abstract excerpt

<title>Abstract</title> <p>β-cell dysfunction, manifested as impaired glucose-stimulated insulin secretion (GSIS), and β-cell loss, presented as dedifferentiation, inhibited transcriptional identity and death, are the hallmarks of type 2 diabetes. Trimethylamine N-oxide (TMAO), a gut microbiota metabolite, has been shown to play a role in cardiovascular disease. Here, we found that plasma TMAO levels are elevated...

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Literature Corpus work: 728cd444-11c6-575f-85ce-3416723b8562
DOI: 10.21203/rs.3.rs-2465481/v1

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