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Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons

1 Apr 2025

Abstract excerpt

The gut microbiota and its metabolites are bi-directionally associated with various human illnesses, which has received extensive attention. Trimethylamine N-oxide (TMAO) is a gut microbiota metabolite produced in the liver, which may serve the role of an "axis" connecting the gut and host organs. TMAO levels are significantly higher in the blood of individuals with cardiovascular, renal, neurological, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40322030
DOI: 10.2147/dddt.s512207

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