Article

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine<i>N</i>-oxide with implications for heart and kidney disorders

2022-11-08

Abstract excerpt

<h4>Objectives</h4> The host-microbiota co-metabolite trimethylamine N -oxide (TMAO) is linked to increased thrombotic and cardiovascular risks. Here we, sought to i) characterize which host variables contribute to fasting serum TMAO levels in real-life settings ii) identify potential actionable therapeutic means related to circulating TMAO. <h4>Design</h4> We applied “explainable” machine learning, univariate-, m...

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Literature Corpus work: 7d6a5ea8-d619-59d8-9177-6f6a594e9fa7
DOI: 10.1101/2022.11.08.22282073

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