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Article

Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB.

Journal of the American Heart Association - 22 Feb 2016

Seldin Marcus M, Meng Yonghong, Qi Hongxiu, Zhu WeiFei, Wang Zeneng, Hazen Stanley L, Lusis Aldons J, Shih Diana M

Abstract excerpt

BACKGROUND: The choline-derived metabolite trimethylamine N-oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk. METHODS AND RESULTS: We explored the impact of TMAO on endothelial and smooth muscle cell function in vivo, focusing on disease-relevant outcomes for atherogenesis. Initially, we observed that aortas of LDLR(-/-) mice fed a choline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26903003
DOI: 10.1161/JAHA.115.002767
PMCID: PMC4802459

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LDLR

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Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB.PMID 26903003Read ↗

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