Article

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s disease

2025-06-04

Abstract excerpt

Crohn’s disease (CD) is a heterogeneous disease characterized by chronic inflammation of the gastrointestinal tract driven by an aberrant immune response. To understand the immune mechanisms underlying mucosal inflammation, we performed single-cell RNA sequencing on paired terminal ileum biopsies and blood samples from 125 CD patients. Our findings reveal that the transcriptional profiles of immune cells are prima...

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Literature Corpus work: 890b9a91-a64b-50ed-a260-b1781326d6fe
DOI: 10.1101/2025.06.03.25328858

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