Article

Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist

2020-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Cytomegalovirus (CMV)-based vaccines show promising effects against chronic infections in non-human primates. Therefore, we examined the potential of HBV vaccines based on mouse CMV (MCMV) vectors expressing the small HBsAg. Immunological consequences of vaccine virus attenuation were addressed by either replacing the dispensable gene m157 (‘MCMV-HBs’) or the gene M27 (‘ΔM27-HBs’), the latter...

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Literature Corpus work: cdce9d2e-89f6-5001-915b-c6cdcbf729be
DOI: 10.1101/2020.01.29.924787

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