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Article

STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist

9 May 2018

Abstract excerpt

ABSTRACT A pathogen encounter induces interferons, which signal via Janus kinases and STAT transcription factors to establish an antiviral state. However, the host and pathogens are situated in a continuous arms race which shapes host evolution toward optimized immune responses and the pathogens toward enhanced immune-evasive properties. Mouse cytomegalovirus (MCMV) counteracts interferon responses by...

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Identifiers

PMID: 29743368
DOI: 10.1128/jvi.00296-18

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