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Article

Therapeutic HBV vaccine efficacy through ancestral mismatched T cell epitopes

2026-05-07

Abstract excerpt

<title>Abstract</title> <p>Therapeutic vaccines for the treatment of chronic viral infections, such as HBV, have been mainly designed to target conserved viral regions and to preferentially restore dysfunctional virus-specific CD8 T cells. Such vaccines have failed to deliver clinical benefit, but a recent trial combining siRNA Elabsiran and PEG-IFN-α reported a remarkable ~50% HBsAg loss rate in chronic HBV pati...

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Literature Corpus work
315eb84e-9ef6-58b3-a751-2c626e13e235
DOI
10.21203/rs.3.rs-8892351/v1
Open publication

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Therapeutic HBV vaccine efficacy through ancestral mismatched T cell epitopesDOI 10.21203/rs.3.rs-8892351/v1
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