Article

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

2021-02-16

Abstract excerpt

Human cytomegalovirus (HCMV) microRNAs (miRNAs) significantly rewire host signaling pathways to support the viral lifecycle and regulate host cell responses. Here we show that SMAD3 expression is regulated by HCMV miR-UL22A and contributes to the IRF7-mediated induction of type I IFNs and IFN-stimulated genes (ISGs) in human fibroblasts. Addition of exogenous TGFβ interferes with the replication of a miR-UL22A mut...

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Literature Corpus work: 8d314bb2-495f-57cb-a38b-b3f5eb438640
DOI: 10.1101/2021.02.16.431411

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