Adaptive Immune Responses Elicited by Baculovirus and Impacts on Subsequent Transgene Expression <i>In Vivo</i>

Abstract excerpt

Baculovirus (BV) is a promising gene therapy vector and typically requires readministration because BV mediates transient expression. However, how the prime-boost regimen triggers BV-specific adaptive responses and their impacts on BV readministration, transgene expression, and therapeutic/vaccine efficacy remain unknown. Here we unraveled that BV injection into BALB/c mice induced the production of BV-specific...

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