Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.

doi:10.1093/infdis/jiad340

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.

The Journal of infectious diseases - 12 Apr 2024

Schmidt Sarah, Mengistu Meron, Daffis Stephane, Ahmadi-Erber Sarah, Deutschmann Daniela, Grigoriev Tetiana, Chu Ruth, Leung Cleo, Tomkinson Adrian, Uddin Mohammad Nizam, Moshkani Safiehkhatoon, Robek Michael D, Perry Jason, Lauterbach Henning, Orlinger Klaus, Fletcher Simon P, Balsitis Scott

Abstract excerpt

Hepatitis B Virus (HBV) is a major driver of infectious disease mortality. Curative therapies are needed and ideally should induce CD8 T cell-mediated clearance of infected hepatocytes plus anti-hepatitis B surface antigen (HBsAg) antibodies (anti-HBs) to neutralize residual virus. We developed a novel therapeutic vaccine using non-replicating arenavirus vectors. Antigens were screened for genotype conservation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Hepatitis B

Share to Hepatitis B Antibodies

Share to Hepatitis B Surface Antigens

Share to Hepatitis B Vaccines

Share to Hepatitis B virus

Share to Immunization

Source

Open in PubMed

Identifiers

PMID: 37602681
DOI: 10.1093/infdis/jiad340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.PMID 37602681Read ↗

A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytesSemantic proximity Read ↗

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animalsSemantic proximity Read ↗

DNA vaccine cocktail expressing genotype A and C HBV surface and consensus core antigens generates robust cytotoxic and antibody responses in mice and Rhesus macaques.Semantic proximity Read ↗

Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.Semantic proximity Read ↗

A pan-genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice.Semantic proximity Read ↗

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After TrialSemantic proximity Read ↗

Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes.Semantic proximity Read ↗

Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.Semantic proximity Read ↗

The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes.Semantic proximity Read ↗

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.Semantic proximity Read ↗

Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteinsSemantic proximity Read ↗

The development of a pan-genotypic T cell vaccine against hepatitis C virus using heterologous prime-boost strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.