Article
Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance.
Nature communications - 14 Dec 2017
Shen Zhongliang, Yang Huijuan, Yang Sisi, Wang Wei, Cui Xiaoxian, Zhou Xian, Liu Wei, Pan Shaokun, Liu Yanfeng, Zhang Junqi, Zhang Jiming, Xie Youhua, Liu Jing
Abstract excerpt
Hepatitis B virus (HBV) generally causes self-limiting infection in immunocompetent adults, but establishes chronic infection in some adults and in most maternally infected infants. Factors determining clearance versus persistence are not fully understood. Hydrodynamic injection (HDI) of HBV replicon plasmid via tail vein generally results in quick clearance in immunocompetent adult mice. Here, we report the...
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